Susie Essman has played the venomous Susie Greene for all six seasons of the critically-acclaimed HBO comedy series, Curb Your Enthusiasm. Susie is the no-nonsense wife of Larry David's rotund, cheerful agent Jeff Greene. Mrs. Greene will not suffer a fool or overlook the slightest slight; she invariably sees through every one of Larry and Jeff's lies and mischievous ploys and rips into them. These hilarious bouts of withering sarcasm and uninhibited insults have become her character's trademark and helped her to become one of the most popular players on the show.

The New York Times calls Susie "one of the most vivid characters in the show, whose off-color tantrums have become an audience favorite the way Kramer’s clumsy entrances once were". The New York Observer (which calls her "fantastic") says "she's taken female cursing to longshoreman levels, pummeling her bumbling, barrel-bodied husband with potty-mouthed invectives like 'You fat fuck!'", and Newsweek refers to her as "the incomparable Susie Essman, every 'Curb' fan’s favorite supporting player".